What is the role of macrophages in the fight against obesity?
Macrophages are specialized cells that act as the body’s first line of defense against pathogens, initiate tissue repair and orchestrate immunity. In metabolic disorders like obesity, macrophages play a critical role in regulating the body’s energy balance, as they control the ability of adipose tissue to store, burn and release energy. By interacting with other immune cells and adjacent tissue, macrophages help control how much fat is stored. They also regulate inflammation, adipose tissue remodeling, and angiogenesis (the formation of new blood vessels). Macrophages also release cytokines that help regulate energy balance, and can be used as therapeutics to help decrease body fat, increase fat burning, and improve insulin sensitivity.
What if we moved the Earth away from the Sun?
If the Earth was moved away from the Sun, the temperature of the planet would drastically drop. Liquid water would most likely freeze and all life on Earth as we know it would likely die out.
How does a mandated benefit affect an insurance premium?
A mandated benefit is a benefit required by law that must be included in an insurance policy. Having a mandated benefit in an insurance policy will typically increase the total premium paid. This increase is due to the additional amount of coverage required. The increased amount of insurance coverage will be reflected in the overall premium required for the policy.
How much do slot machines have to return to the tribes?
Native American tribes are typically granted the right to operate slot machines in exchange for a percentage of revenue. That percentage varies from tribe to tribe and is agreed upon when the tribal-state gaming compact is signed.